MINIMALLY INVASIVE VERSUS OPEN TOTAL GASTRECTOMY (MEGA): STUDY PROTOCOL FOR A MULTICENTRE RANDOMISED CONTROLLED TRIAL (DRKS00025765)

Minimally invasivE versus open total GAstrectomy (MEGA): study protocol for a multicentre randomised controlled trial (DRKS00025765)

Introduction The only curative treatment for most gastric cancer is radical gastrectomy with D2 lymphadenectomy (LAD).Minimally Test invasive total gastrectomy (MIG) aims to reduce postoperative morbidity, but its use has not yet been widely established in Western countries.Minimally invasivE versus open total GAstrectomy is the first Western multi

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Color-induced changes in Chrysanthemum morifolium: an integrative transcriptomic and metabolomic analysis of petals and non-petals

Chrysanthemum morifolium (CM), renowned for its diverse and vibrant varieties, holds significant ornamental and medicinal value.Despite this, the core regulatory mechanisms underlying its coloration, especially in non-petal tissues (i.e., the parts of CM that do not include petals, such as the reproductive tissues, receptacle and calyx), have been

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The Effect of Sampling Bias on Evaluating the Diversity and Distribution Patterns of Iranian Spiders (Arachnida: Araneae)

Although spiders constitute a highly thigh-strapon diversified group of animals, the knowledge regarding their geographic distribution (i.e., the so-called Wallacean shortfall) and diversity patterns is incipient on a global scale; while attempts to explore such patterns have been made for the highly diversified Neotropical fauna, several Old World

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USP5 enhances SGTA mediated protein quality control.

Mislocalised membrane proteins (MLPs) present a risk to the cell due to exposed hydrophobic amino acids which cause MLPs to aggregate.Previous studies identified SGTA as a key component of the machinery that regulates the quality control of MLPs.Overexpression of SGTA promotes deubiqutination of MLPs resulting in their accumulation in cytosolic inc

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